منابع مشابه
Pathophysiology of Cystic Fibrosis
Understanding the development of lung disease in cystic fibrosis (CF) has been a sought after goal for several decades. With the cloning of the CF transmembrane conductance regulator (CFTR) gene and other advances in the study of airway epithelial biology, a much clearer picture of disease pathophysiology has emerged. Our best available evidence points to dysregulated ion transport as the under...
متن کاملPathophysiology and therapeutic potential of cardiac fibrosis
Inflammatory and fibrotic responses to myocardial damage are essential for cardiac repair; however, these responses often result in extensive fibrotic remodeling with impaired systolic function. Recent reports have suggested that such acute phase responses provide a favorable environment for endogenous cardiac regeneration, which is mainly driven by the division of pre-existing cardiomyocytes (...
متن کاملPathophysiology of gadolinium-associated systemic fibrosis.
Systemic fibrosis from gadolinium-based magnetic resonance imaging contrast is a scourge for the afflicted. Although gadolinium-associated systemic fibrosis is a rare condition, the threat of litigation has vastly altered clinical practice. Most theories concerning the etiology of the fibrosis are grounded in case reports rather than experiment. This has led to the widely accepted conjecture th...
متن کاملEpidemiology, Pathophysiology, and Prognostic Implications of Cystic Fibrosis–Related Diabetes
C ystic fibrosis–related diabetes (CFRD) is the most common comorbidity in subjects with cystic fibrosis (CF). A consensus conference on CFRD was cosponsored by the Cystic Fibrosis Foundation (CFF), the American Diabetes Association (ADA), and the Pediatric Endocrine Society (PES) in September 2009. The committee’s evidencebased recommendations for clinical management of CFRD are published in t...
متن کاملUnravelling the progressive pathophysiology of idiopathic pulmonary fibrosis.
Idiopathic pulmonary fibrosis (IPF) is a life-threatening condition, with a median survival of <3 yrs. The pathophysiology is not fully understood, but chronic injury of alveolar epithelial type II cells (AECII) is considered key. In IPF, disturbed folding and processing of surfactant proteins and impaired DNA repair may represent underlying reasons for maladaptive endoplasmic reticulum stress ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Tuberculosis and Respiratory Diseases
سال: 1988
ISSN: 1738-3536,2005-6184
DOI: 10.4046/trd.1988.35.2.88